Jean-Pierre Changeux


Prix Balzan 2001 pour les neurosciences cognitives

Projet de recherche  

Neuronal Organization of the Brain and Cognitive Functions

Jean-Pierre Changeux is Professor Emeritus at the Institut Pasteur and Honorary Professor of the Collège de France. In his research, Changeux was mainly concerned with the study of the correlation of cognitive functions and the molecular aspects of cerebral activity. His laboratory was the first to activate the genes of neuronal nicotinic receptors and to study the consequences they might have on human behaviour. Jean- Pierre Changeux used the second half of his Balzan Prize to continue and diversify this research at the Récepteurs et Cognition unit of the Institut Pasteur. General overviews of this research are contained in the publications listed below. In the Nature Reviews Neuroscience article, Changeux reviews studies in transgenic mice that started to reveal which nicotine receptor subunits mediate the effects of nicotine on behavior, cognition and addiction, thus forming therapeutic targets for nicotine addiction.

Main Publications
Changeux J-P. 2010. Nicotine addiction and nicotinic receptors: lessons from genetically modified mice. Nature Reviews Neuroscience.
Changeux J-P, Edelstein SJ. 2005. Nicotinic Acetylcholine Receptors: From Molecular Biology to Cognition. Paris-New York: Editions Odile Jacob.

Excerpt from the: The Balzan Prizewinners’ Research Projects: An Overview 2018