David Baulcombe

2012 Balzan Prize for Epigenetics

For his fundamental contribution to the understanding of epigenetics and its role in cell and tissue development under normal and stressful conditions.

Among his most important publications, we would mention:
– Shivaprasad, P.V.; Dunn, R.M.; Santos B.A.; Bassett A.; Baulcombe D.C. (2012). “Extraordinary transgressive phenotypes of hybrid tomato are influenced by epigenetics and small silencing RNAs”. The EMBO Journal 31 (1); 257-266.
– Molnar, S.; Melnyk C.W.; Bassett, A.; Hardcastle, T.J.; Dunn, R.; Baulcombe, D.C. (2010). “Small Silencing RNAs in plants are mobile and direct epigenetic modification in recipient Cells”. Science 328 (5980); 872-875.
– Chen, H.M.; Chen, L.T.; Patel, K.; Li, Y.H.; Baulcombe, D.C.; Wu, S.H. (2010). “22-nucleotide RNAs trigger secondary siRNA biogenesis in plants”. Proceedings of the National Academy of Sciences of the United States of America 107 (34); 15269-15274.
– Mosher, R.A.; Melnyk C.W.; Kelly K.A.; Dunn R.M.; Studholme D.J.; Baulcombe D.C. (2009). “Uniparental expression of PolIV-dependent siRNAs in developing endosperm of Arabidopsis”. Nature 460; 283-U151.
– Mosher, R.A.; Schwach, F.; Studholme, D.; Baulcombe, D.C. (2008). “PollVb influences RNA-directed DNA methylation independently of its role in siRNA biogenesis”. Proceedings of the National Academy of Sciences of the United States of America 105 (8); 3145-3150.
– Herr, A.J.; Jensen, M.B.; Dalmay, T; Baulcombe, D.C. (2005). “RNA polymerase IV directs silencing of endogenous DNA”. Science 308 (5718); 118-120.
– Baumberger, N.; Baulcombe, D.C. (2005). “Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs”. Proceedings of the National Academy of Sciences of the United States of America 102 (33); 11928-11933. E
– Hamilton, A.; Voinnet, O.; Chappell, L.; Baulcombe, D.C. (2002). “Two classes of short interfering RNA in RNA silencing”. The EMBO Journal 21 (17); 4671-4679.
– Jones, L.; Ratcliff, F.; Baulcombe, D.C. (2001). “RNA-directed transcriptional gene silencing in plants can be inherited independently of the RNA trigger and requires Met1 for maintenance”. Current Biology 11 (10); 747-757.
– Dalmay, T.; Hamilton, A.; Rudd, S.; Angell, S.; Baulcombe, D.C. (2000). “An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus”. Cell 101 (5); 543-553.
– Hamilton, A. J.; Baulcombe, D.C. (1999). “A species of small antisense RNA in posttranscriptional gene silencing in plants”. Science 286 (5441); 950-952.
– Voinnet, O.; Baulcombe, D.C. (1997). “Systemic signalling in gene silencing”. Nature 389; 553.
– Baulcombe, D.C. (1986). “RNA as a target and an initiator of post-transcriptional gene silencing in transgenic plant”. Plant Molecular Biology 32 (1-2); 79-88.

(September 2012)

Insert your email address here to sign up for our newsletter with all the latest updates on the International Balzan Prize Foundation .

First name
Last name
By subscribing, I confirm that I have read and understand the General Terms and Conditions of EU Regulation 2016/679, in particular with regard to my rights, and hereby consent to the processing of my personal in the manner and for the purposes indicated therein.
Fondazione Internazionale Premio Balzan